Rebelle Pro Digital Painting Software
I took advantage of the $10 sale going on now. I've only briefly tried it out but am very impressed so far.
The brushes/media texture handling etc. are very impressive.
Of course it works best with a drawing tablet but that's true of any digital art application.
I doubt it's going to replace Painter or Krita in my toolbox but ya never know.
https://www.escapemotions.com/products/rebelle/about?//products/rebelle/index.php