Ein bis drei von 100 Coronainfektionen dauern länger als 30 Tage an. Die meisten der Betroffenen erlebten ein Auf und Ab der Viruslast und haben ein erhöhtes Long-Covid-Risiko.#LongCovid #Corona #Infektion #Sars-CoV-2 #Erkältung #Medizin
Hartnäckige Coronainfektionen häufiger als bislang angenommen
Ein bis drei von 100 Corona-Infektionen dauern länger als 30 Tage an. Die meisten der Betroffenen erlebten ein Auf und Ab der Viruslast und haben ein erhöhtes Long-Covid-Risiko.#LongCovid #Corona #Infektion #Sars-CoV-2 #Erkältung #Medizin
Hartnäckige Corona-Infektionen häufiger als bislang angenommen
Das antivirale Mittel Simnotrelvir lindert Fieber, Husten und Schnupfen bei Patienten, die kein hohes Risiko für schwere Verläufe haben. Bislang ist es nur in China zugelassen.#Corona #Covid-19 #Pandemie #Sars-CoV-2 #AntiviraleMedikamente #Simnotrelvir #LeichterVerlauf #Medizin
Neues Medikament verkürzt milde Corona-Verläufe
Wenn Epoch Times das schreibt, dann muss es stimmen.
♲ Epoch Times DE - inoffiziell - 2023-10-12 07:49:05 GMT
Wissenschaftler entdecken Zusammenhang zwischen Impfspikes und Übersterblichkeit. Durch Vakzine injizierte Spike-Proteine sind noch Monate später im menschlichen Gewebe nachweisbar und müssen daher für dauerhafte Erkrankungen in Betracht gezogen werden.#Biontech #Corona #Cullen #Impfstoff #Impfung #König #Lipidnanopartikel #modRNA #mRNA #Pandemie #Pfizer #Proteine #Rohrig #Sars-CoV-2 #Spike #Spikeproteine #Vakzin #Wissenschaftler #EpochTimesPlus #Gesellschaft #TopStories
"The pandemic" " #The #virus" " #Covid-19" " #Infection" " #Contagion"
Repeat these words a few trillion times and keep repeating them in every major #media outlet and in all conventional literature as if they were the gospel truth--and show them coming out of the mouths of all government officials and all major public figures--and people will eventually believe the story they're being told, no matter what the evidence from their senses and their life experience actually indicates.
What we are witnessing in this Covid era is literally the making of a #mythology. Unfortunately, unlike whimsical myths about cyclops and mermaids, this myth--because of how it has been used and will continue to be used by the murderous maniacs in power--is the greatest threat our species has ever faced. We must do everything humanly possible to expose it for what it really is: the biggest, most dangerous #LIE in #history.
THERE IS NO VIRUS
https://www.brighteon.com/a4755e76-befc-467c-9a1e-b6d758f8552e
Excellent in-depth article by microbiologist #Dr. #MarkBailey:
-- A #Farewell To #Virology (Expert Edition)
Virology invented the virus model but has consistently failed to fulfil its own requirements. It is claimed that viruses cause disease after transmitting between hosts such as humans and yet the scientific evidence for these claims is missing. One of virology’s greatest failures has been the inability to obtain any viral particles directly from the tissues of organisms said to have “viral” diseases. In order to obfuscate this state of affairs, virologists have resorted to creating their own pseudoscientific methods to replace the longstanding scientific method, as well as changing the dictionary meaning of words in order to support their anti-scientific practices. For instance, an “isolated” isolate does not require the physical existence of the particles in order to be afforded “isolation” status.
A viral particle must fulfil defined physical and biological properties including being a replication-competent intracellular parasite capable of causing disease in a host such as a human. However, “viruses” such as SARS-CoV-2 are nothing more than phantom constructs, existing only in imaginations and computer simulations. In this paradigm, cases of invented diseases like COVID-19 are nothing more than the detection of selected genetic sequences and proteins purported to be “viral.” The existence of a virus is not required in this loop of circular reasoning and thus entire “pandemics” can be built upon digital creations and falsely sustained through in vitro (“test tube”) molecular reactions. . . .
#SARS-CoV-2 remains nothing more than a hypothetical #computer #construct, assembled from genetic fragments of unproven provenance. There has never been a physically isolated (i.e. purified) particle shown to be responsible for the production of identical particles or a particle shown to be the cause of pathological effects in any human or in an experimental animal model. Thus, the declaration by virologists such as Van Ranst, along with the WHO and its adherents, that an infectious particle termed ‘SARS-CoV-2’ is causing a disease pandemic is shown to be patent scientific and intellectual #fraud.
It is hard to know exactly what to call virology, but it is not science. The current practitioners are engaging in some form of algorithmic or statistical speculation added to circular reasoning and confirmation bias, with a complete absence of what should be the corresponding process of refutation that lies at the heart of the scientific method.
Because a scientific theory demands evidence that has repeatedly been tested and corroborated in accordance with the scientific method, it is clear that “viruses” never even reached the stage of a theory. According to the science, they remain mere speculation.
https://drsambailey.com/a-farewell-to-virology-expert-edition/
#CHILDREN'S #HEALTH #DEFENSE & #NON-EXISTENT ' #SARS-COV-2' - ERIC COPPOLINO, CHRISTINE MASSEY & MICHAEL B
#virusScam #vaccinescam years and years of lies and corruption #democide
https://www.bitchute.com/video/avTEYCW2tq0j/
Kopfschmerzen, Schwäche, Gedächtnis- und Schlafstörungen - die vielfältigen Symptome von Long COVID sind auf vier biologische Hauptursachen zurückzuführen, sagen Forschende. Die Psyche sei keine davon.#LongCOVID #COVID-19 #Coronavirus #SARS-CoV-2 #Viren #Autoimmunität #Herpes #Epstein-Barr-Virus #Immunologie #Impfung #Leopoldina
Forschende identifizieren vier Hauptursachen für Long COVID | DW | 02.02.2023
Deutschlands berühmtester Virologe zeigt sich optimistisch: Wenn kein Mutationssprung auftaucht, wird es nur noch kleine COVID-19-Wellen geben, sagt Christian Drosten. Ein anderer Experte sieht das ähnlich.#Corona #Pandemie #ChristianDrosten #Endemie #SARS-CoV-2
Christian Drosten ruft Ende der Corona-Pandemie aus | DW | 26.12.2022
https://www.sott.net/article/474668-What-is-causing-the-blood-clots-from-Died-Suddenly (pasted beneath).
eyes open, no fear, stay safe everybody.
there are many important passages in this article, which i could cut out individually to highlight, but i think it important you read the whole thing.
#goodarticle #goodread #covid #forprofitmedicine #spikeprotein #amyloid #normalpeoplesaveeerybody #clot #clots #clotting #sars-cov-2 #medicine #vaccine #notavaccine #fakeccine #blood #fibrin #study #science #life #disease #health #Creutzfeldt-JakobDisease #CreutzfeldtJakobDisease #CJD #prion #CDR #spikeprotein #proteinfolding #erythrocyteagglutination #platelethyperactivation #membranespreading #fraud #sott #zeta #cull #plateletderivedmicroparticle #centralnervoussystem #nanoparticles #DiedSuddenly #history #elitistpopulationcontrol #depopulation #evidence #summary #sterilizingvaccine #rapidclumping #longchainofaminoacids #aminoacids #mRNA #programmed #Pfizer #cardiac #PPP #amyloidosis #myocarditis #colloidalstability #homeostasis #trypsinization #colloidalsolutions #clump #balance #electricalcharges #complexbalance #safetyconcerns #aluminum #aluminium #T2DM #agglomeratingcolloidalsuspensions #blood #microstrokes #bloodviscosity #cardiovasculardisorders #circulatorydisorders #censorship #cantdoscienceundercensorship #unusualsymptoms #genuinesympathy #oversights #complexsubjects #bestefforts #factualerrors #misinformation #medicalinformation #BigPharmaassassinations #embalmers #convincing #compelling #thepublic #majorproblems #principle #thescientificcommunity #entrencheddogmas #bigotry #stubbornprejudices #dogma #dogmaoverturned #proof #alternativeargument #canbedirectlyseen #forthosewitheyestosee #ifyoulook #keeplooking #searchforthetruth #corrections #newevidence #forpeoplewhothink #wellness #doctor #medicine #redbloodcells #veins #arteries #physiology #biology #fibrousclots #hypothesis #evidence #exploration #extrapolation #explanation #bloodclots #largeclots #microclots #frequentclots #deadlyclots #unusualclots #d-dime #sn-102 #enzymes
#rage #solutions #lookforsolutions #questionmore #questioneverthing #followingthescienceisnotdoingscience #cantgettherefromhere #eyesopennofearstaysafeeverybody
#wecanstillmendthis #nocullnecessary
quick n dirty copy pasta of whole page :
Welcome to Sott.net
Thu, 01 Dec 2022
The World for People who Think
Health & Wellness
Red Pill
What is causing the blood clots from 'Died Suddenly'?
A Midwestern Doctor
The Forgotten Side of Medicine
Fri, 25 Nov 2022 00:00 UTC
red blood cells
© shutterstock illustration
Red blood cells in vein
The SARS-CoV-2 spike protein is remarkably effective at disrupting many critical physiologic processes both in the short term and in the long term.
I have always been drawn to understanding pharmaceutical injuries, and for years I've participated in support groups for a variety of different toxic pharmaceuticals (e.g. Lupron or Ciprofloxacin and other fluoroquinolones). In addition to being able to witness the human costs of these drugs firsthand (and the gaslighting those forgotten patients experience), this exploration has given me a great deal of perspective on the shared and differing toxicities these drugs share along with what methods can help the myriad of seemingly unrelated symptoms that emerge.
Once the COVID-19 vaccine rollout started, my focus understandably shifted toward them. Although many of the pathologies I saw resembled what I had seen with other toxic drugs (and to some degree responded to the same therapies), there was also a lot I had not seen before, which demonstrated these vaccines were in a different league of toxicity from what I was used to. I have thus spent the last two years trying to understand exactly how these vaccines kill and injure people.
Visual Persuasion
The documentary Died Suddenly was recently released and went viral. I am personally a bit torn on this movie because it covers a lot of important ground and is presented in a highly persuasive manner that will red-pill many who are on the fence, but it also has a variety of errors and tangental conspiratorial content which makes it prone to being debunked and discrediting this message to those who were on the fence about it.
One of the challenges we have reached in the current political system (concisely articulated by Scott Adams) is that for many "facts don't matter; persuasion is everything." Because we live in a sea of information, that information is overloading and people typically default to selecting the "facts" which are presented to them in the most persuasive manner possible (e.g. in an emotionally provocative manner or by being spammed simultaneously on every media source). This is also why I believe understanding the propaganda which underlies the medical-industrial complex is so important for one's health and why that was the focus of my previous article.
One of Scott Adams' key points is that visual metaphors tend to be the most persuasive because they are easy for the audience to comprehend and viscerally experience (this was a rhetorical tactic frequently utilized by Trump). I have often thought about this point in regard to heart disease, as the cholesterol hypothesis (which has made billions upon billions off toxic cholesterol-lowering drugs) for decades has failed by every metric, is completely unsupported by the evidence (this subject is further discussed here), yet despite all of that, the cholesterol hypothesis persists.
I believe the marketing genius behind the cholesterol hypothesis lies in how visually persuasive it is. This is because cholesterol obstructing the arteries (which is not what actually happens) can easily be analogized to a fat-clogged sewage pipe, and once the idea is explained to people it, along with the disgust it elicits can easily be visualized by a member of the public.
clogged pipe
In the case of the COVID-19 vaccines, although they have a variety of issues, the unique blood clots they form once observed in autopsies also fulfill that requirement, and hence are a home run for persuasion. Similarly, I felt their section represented by far the most persuasive part of Died Suddenly and for that reason, I created a 15-minute abridged version of the documentary only containing the sections focusing on blood clots. Keeping the previous in mind, watch this and notice how persuasive it is to you (I believe this is the primary part of the video that is red-pilling people). Scenes in this video will also be important for understanding technical details within later parts of the article.
Pretty convincing wouldn't you say?
Unfortunately, as alluded to above, there is one huge issue with this segment. The live clot at the end has nothing to do with the COVID-19 vaccinations (it came from a surgery posted on youtube a year before the vaccines entered the market). I suspect this arose because someone re-uploaded that clip and labeled it as being from the vaccines (either as a prank or as clickbait) and then it was re-shared until the Died Suddenly team got it and added it in since it supported their narrative. This illustrates why it is so important to have strict editorial controls on any production, especially one that is difficult to revise after the fact and will be viewed by large numbers of people. I debated clipping that ending part off (since it makes this a much worse clip to share), but did not as I felt it is important for our community to be transparent and open about any inaccuracies on our end.
This clip has also inspired other readers to investigate these claims. They sadly have reported a similar situation to that being seen in the medical field. Readers have also told me directly that funeral home directors when spoken to will admit they are seeing these clots but are afraid to speak out on this issue as they fear losing their businesses and livelihoods (e.g. one funeral home in Washington was cancelled for doing so). After publishing this article, a reader (I verified the credentials of) who works at funeral homes in the South also reached out and attested that although blood clots are not rare at all to see during the embalming process, they and colleagues have started seeing large clots like those described here that have never been observed before.
The Blood Clot Mystery
A significant portion of my focus on the COVID-19 vaccination issue has revolved around trying to understand what is causing these unusual blood clots (both the coffee ground looking microclots and the large fibrous clots). I view the blood clots as being particularly important as they may be the key to understanding why a delayed death effect (often taking around 5 months) is frequently observed in vaccine recipients.
Before we go further, I would like to note that the best article (courtesy of the Epoch Times) I have seen summarizing the characteristics of these clots can be found here and is thus an important reference piece for understanding this question. One of the key points this article illustrates is that the elemental composition of these fibrous structures indicates they are not primarily forming from blood (e.g. they may be in regions of poor circulation). Another key point is that smaller normal blood clots (as shown within Died Suddenly) could be found at the terminal regions of the fibrous clots suggesting they may have originated there and that a normal process had initiated at these clots but then gone awry.
At this point, I have heard more hypotheses than I can count that many sincerely believe in. These include:
- These are normal blood clots being misinterpreted by large numbers of embalmers who have been sucked into a mass formation and any post-mortem clot would look like that if it was preserved in the manner the embalmers chose to do so here.
- The mRNA vaccines also somehow produce synthetic toxic proteins inside the body that self-assemble into these deadly blood clots.
- These fibrous clots are self-assembling nanotechnology whose growth somehow responds to 5G or Bluetooth.
Because these fibrous clots are so unusual they have understandably provoked a great deal of confusion and uncertainty which has led many to grasp for rather unusual explanations over what is occurring. In situations like these, I believe that if a simple and comprehensive explanation can be identified, that represents the best approach for addressing this dilemma. Fortunately, one has been.
What Creates the Fibrous Clots?
Two months ago I put forward the model I believe best explains what is occurring (for those wishing to learn more, the article below goes into a significant degree of detail that is beyond the scope of today's article):
The long and short of it was that this largely unknown August 2021 paper explains exactly why these fibrous clots are forming.
In the study, a blood clotting simulation outside the body was created. Normal blood, blood from COVID-19 patients on the first day of symptoms before any treatment, and normal blood exposed to a low concentration of COVID-19 spike proteins were then exposed to a key clotting factor, thrombin. When those clots were observed the study found:
Normal blood behaved as expected.
Normal blood with dilute spike protein formed a denser fibrin clot.
Small amounts of amyloid (abnormal protein aggregations) were present in the fibrin clots formed.
Much more (a statistically significant increase) in amyloid was present in the fibrin clots formed by normal blood mixed with dilute spike protein.
To illustrate the differences (the green signal corresponds to amyloid detection):
4 PPP boxes
When these blood samples were then studied in a simulation of blood flow, it was observed that while normal blood created regular clots on the side of blood vessel walls, once the spike protein was involved (either through an acute COVID-19 infection or dilute spike protein being added), the fibrin clots became irregular, in the case of COVID-19 resisted removal from blood vessel walls, and due to their size and irregularity, obstructed critical flow within the vessel.
Note: I have also observed massive highly unusual blood clots in critically ill hospitalized patients with COVID-19 that required surgical removal, such as a dear friend who refused to vaccinate and got very ill from delta. Large COVID-19 clots are much rarer than what is being observed with the vaccine and as of now I have not been able to verify if they had the same fibrous characteristics.
Boxes ABCDEF
Similarly, when the blood was looked at under electron microscopy, significant structural abnormalities could be seen:
electron microscope images
The most important finding of the study can be found at the end:
Mass spectrometry showed that when spike protein is added to healthy PPP, it results in structural changes to β and γ fibrin(ogen), complement 3, and prothrombin. These proteins were substantially resistant to trypsinization, in the presence of spike protein.
In short, the authors found that when spike protein was added to blood samples, it caused irregular (misfolded) fibrous clots to form that were resistant to the enzymes researchers and the body (e.g. the digestive system) uses to break down protein structures. This most likely means the enzyme the body typically uses to break down fibrin clots cannot do so for these misfolded fibrous clots.
It should also be noted that COVID-19 blood clots and vaccine blood clots do not respond to many of the anticoagulants that traditionally are effective, further suggesting misfolded blood clots are a key aspect of the disease process (my team also suspects the spike protein directly interacts with clotting factors, e.g. it appears to bind and inactivate heparin, a commonly used anticoagulant which also stabilizes the zeta potential of the body).
The authors further discussed these misfolded clots and cited their potential role in long-haul COVID-19 as a rationale for the current experiment described here which sought to determine the effects of adding spike protein to normal blood:
Interestingly, plasma from T2DM and form healthy individuals, immediately digested fully after a first trypsinization step, however, persistent microclots remained in the plasma samples from Long COVID/PASC and from acute COVID-19 samples, still contained large anomalous (amyloid) deposits (microclots). After a second trypsinization, the persistent pellet deposits were solubilized. We detected various inflammatory molecules that are substantially increased in both the supernatant and trapped in the solubilized pellet deposits of acute COVID-19 and Long COVID/PASC, versus the equivalent volume of fully digested fluid of the control samples and T2DM. Of particular interest was a substantial increase in α(2)-antiplasmin (α2AP), various fibrinogen chains in both acute COVID-19 and Long COVID/PASC digested microclots.
In summary, this study demonstrated that there are always slightly irregular or misfolded fibrous blood clots being formed within the body, but at the same time the body has a mechanism for removing them. However, once small amounts of spike protein are added into the mix (at concentrations I believe will be reached through vaccination) those irregular fibrous clots spiral out of control and come to dominate the clotting process. At this point, the body's mechanisms for removing them are no longer able to outpace this growth function and they instead grow until they are constrained in size by the blood vessels they are within like the large fibrous clots shown in Died Suddenly.
This is particularly problematic because the spike protein attacks the endothelium (creating large numbers of initiating events for blood clots) and because the mRNA vaccines were engineered to persist in the body so they could produce enough spike proteins to elicit an antibody response sufficient to meet regulatory approval, which unfortunately led to them continuing to produce toxic spike proteins for a prolonged and possibly indefinite period.
In my own opinion, this study was a pivotal point of data that should have brought an immediate halt to the spike protein vaccine roll-out but instead has languished as a relatively unknown study. Nonetheless, the authors continued their research and later published a more detailed paper on what they had discovered about these fibrin amyloid clots which they proposed as the underlying cause of long-haul COVID (but for political reasons obviously could not link to the vaccine).
Postscript: Following publication of this article, a reader alerted me to this study from a different research time (summarized here) which using another methodology also observed that the spike protein was causing irregular and inflammatory fibrin clots to form which resisted degradation.
Why Does the Spike Protein Cause Misfolding?
Numerous observations suggest that something about the spike protein causes protein misfolding to occur. In addition to the abnormal fibrous clots described above, the spike protein vaccination has also been associated with other misfolding diseases. Rapid cognitive decline in the elderly is frequently observed following COVID-19 vaccination. This observation inspired a recent series in here focused on the actual causes of Alzheimer's disease and other forms of dementia (which are often associated with amyloid plaques in the brain), many of which are rapidly accelerated by the SARS-CoV-2 spike protein, along with the therapeutic strategies for addressing them.
One of the most well-known protein misfolding diseases that leads to dementia, Creutzfeldt-Jakob disease, is an extremely rare and fatal brain disease that occurs in approximately one in a million people. Shortly before he passed, Luc Montagnier published a case report of 26 cases of CJD following vaccination, and since that time others have also observed this link.
Similarly, when my team reviewed a large number of vaccine injury reports submitted to Steve Kirsch in a survey, out of the final 607 submissions analyzed, there were three reports of fatal prion diseases (two of which were specified to be CJD, the third most likely was as well), meaning this disease was observed by approximately 0.5% of respondents (which is much more than the one in a million lifetime occurrence rate). We found this very concerning, especially given that CJD normally takes over a decade to develop, so it was even more worrisome that many cases have already emerged.
Another well-known protein misfolding disorder that has been associated with the spike protein is amyloidosis. Amyloidosis is linked to various severe chronic diseases (Pfizer for example recently invested in a treatment for cardiac amyloidosis so they appear to be aware of this issue).
One paper that examined this issue identified seven regions of the spike protein which fulfilled the structural criteria necessary for the formation of amyloids, and when tested, these regions were found to cause amyloids to form. In the same way that the abnormal fibrous clots gradually build up within the vaccinated until a fatal tipping point is reached, I believe the same may also be occurring with amyloid depositing in the tissue (hence Pfizer's recent investment in cardiac amyloidosis).
Others have also noticed the prion-forming characteristics of the spike protein. One of the most definitive reviews of the subject (by authors including Stephanie Seneff and Peter McCullough) highlighted a variety of mechanisms to explain the prion-forming behavior of the spike protein and its ability to enter the central nervous system (e.g. via the spleen where the vaccine nanoparticles were known to accumulate). Interestingly, authors also noted that of the variants, Delta (which my colleagues suspect was engineered) had a higher score for prionogenesis than the original Wuhan strain, whereas Omicron had a substantially lower score.
Richard Flemming also has done a great deal of work to expose both the lab origin of SARS-CoV-2 and the various treaties its developers violated to do so (and thus must be criminally sentenced for). A key point he makes in an important presentation summarizing his work is that the spike protein used in the synthetic COVID vaccines differs from that of the original SARS-CoV-2 virus, but the one part of the spike protein which was perfectly preserved in the vaccine was the prion-forming section of it. A shortened version of that presentation highlighting the key parts including the prion domain discussion can be found within this article.
In addition to the models demonstrated above, I also believe there is another model which can also explain the protein misfolding and account for the microclots which are occurring.
Zeta Potential and COVID-19
One mission of this Substack has been to bring the concept of zeta potential to the awareness of the general public as I believe it is critical for understanding many different diseases including COVID-19 and both spike protein and non-spike protein vaccine injuries.
When a substance is mixed in water, it has three options, not mix with it (typically either floating to the top or settling to the bottom), dissolve like salt, or form a colloidal suspension. Stable colloidal suspensions are typically finely dispersed microparticles and as that stability is lost, the particles clump together in larger and larger agglomerations which eventually will separate out from the surrounding water.
The colloidal stability of biological solutions however is mostly overlooked in modern physiology (other systems like Chinese medicine through blood stasis hold a greater focus on it). When the colloidal stability of a living organism is sufficiently impaired, severe diseases, such as those created by blood cells clumping together and impairing circulatory function can occur (similarly early researchers showed malaria causes death by creating severe blood clumping in the largest blood vessels, something Pierre Kory has also observed occurs in critically ill patients via IVC ultrasound immediately preceding their deaths).
A key factor that determines if colloidal solutions clump together or remain dispersed is the balance of electrical charges present (positive charges agglomerate, negative charges disperse). Zeta potential provides a way to model this immensely complex balance and explains why tiny amounts of positive ions with high charge densities (e.g. aluminum) are capable of agglomerating colloidal suspensions (e.g. sewage or blood), and why microstrokes often follow injections of these substances (similarly, poor zeta potential increases the viscosity of the blood, and when it is improved, a variety of cardiovascular or circulatory disorders also improved).
When COVID-19 started, I realize that many of the unusual symptoms reported by colleagues were identical to what I would have associated with an agent severely impairing the zeta potential of the body as so many different fluid circulations appeared to be impaired or showing signs of agglomeration (e.g. the frequent blood clots). After some research, I concluded the spike protein had the most likely electrical composition to account for these facts, at which point I became extremely apprehensive over vaccine designs which mass produced spike protein within the body (much of what is now known about the spike protein's toxicity was not known then).
In Fleming's previously mentioned presentation which discussed the prion domain within the vaccine spike protein, he also provided one of the best examples I have seen of how a small amount of a zeta potential reducing agent can rapidly cause blood cells to clump together. This was done by showing the immediate effects of each of the spike protein vaccines on healthy blood (this effect is most likely the result of PEG on the lipid nanoparticles).
The South African researchers quoted earlier in this article likewise observed the same phenomena:
Blood incubated with spike protein showed erythrocyte agglutination, despite the very low concentration of the spike protein. An increase in platelet hyperactivation, membrane spreading, platelet-derived microparticle formation were noted due to spike protein exposure.
Further as detailed here, this clumping is also consistently seen on the blood smears of vaccinated individuals:
2 blue boxes
This rapid clumping process is most likely what causes sudden death immediately following vaccination in susceptible individuals, such as this recent example where this ardent advocate of vaccination died 7 minutes after receiving the new booster in the pharmacy.
As we circle back to Died Suddenly and the abridged version presented here, consider the scenes where the blood of these deceased individuals is shown (I am putting this video in again here so you don't need to scroll up).
When you watch it, three characteristics of that blood should be immediately apparent:
- There are a large number of microclots present (which as discussed here is likely how other zeta potential impairing vaccinations frequently cause neurological injuries).
- It appears more viscous.
- The blood separates from its surrounding plasma (this is best seen in the scenes where it is shown within a test tube, such as the one below).
blood separation
Zeta Potential and Protein Misfolding
Proteins are manufactured by stringing long chains of amino acids together (likewise, the mRNA technology works by directing the body to assemble the specific long chain of amino acids the mRNA was programmed to code for). Once a protein forms, that long chain then folds into a three-dimensional structure that comprises the fully functional protein.
A variety of factors influence that protein folding, and because of the enormous functional consequences of a misfolded protein, a significant focus has been placed the cellular components that prevent this. That discipline has observed states of high stress (e.g. heat shock) inhibit this process for both animal cells and invading microorganisms, and present evidence suggests protein misfolding is a regulatory mechanism cells use to adapt to stress (this is also a foundational principle of the alternative hypothesis of what causes Alzheimer's disease).
In the case of COVID-19, this process appears to play a key role in mediating the diseases process (so a variety of treatments that target it have been explored, although I believe utilizing fevers is probably the most direct solution). I have not been able to find any studies directly assessing the effect of the cytotoxic spike proteins on the regulation of protein folding. However I do know that vaccine injuries are characterized by a chronic activation of the cell danger response, and it is known in the CDR that the heat shock protein response is altered (which plays a large role in protein folding).
Although a great deal of research has gone into observing the factors which influence protein folding, what is often not appreciated about that process is that this folding occurs because the protein chain becomes a suspended colloid in water. As a result the exact shape a protein takes is heavily dependent upon the protein's specific electrostatic interactions with the surrounding environment (and the region of water within the protein).
For this reason, the same factors that influence zeta potential or colloidal stability in other systems also affect protein stability (e.g. the same agents that collapse the physiologic zeta potential are also known denature proteins [lose their folded configuration] and cause them to precipitate out of solution, while those that improve zeta potential stabilize proteins in solutions). One of the easiest models for understanding the denaturation process is when egg whites are heated. Prior to this happening, the colloidally suspended proteins that compose the egg whites are transparent and can easily mix into water, while after this happens they become a solid white mass which separates from water when the two are mixed within (you can also use other denaturing agents besides heat such as alcohol to transform egg whites).
I thus strongly suspect that the physiologic alterations of zeta potential created by a positive charge of the spike protein also affects the folding of a protein and contributes to the protein misfolding detailed within this article. Unfortunately, when I attempted to research this question, I was not able to find any references that I felt adequately assessed it and I was only able to find passing references to it (e.g. a general acknowledgment that denaturing agents impair proper protein folding). Thus, at this time it remains an unproven hypothesis (I feel the papers have to be out there, so once I get them I will revise this position).
Conclusion
For the reasons detailed above, I believe video footage of the unusual blood clots being discovered by embalmers is a winner for convincing the public there are major problems with these vaccines. This principle also holds for the scientific community as entrenched dogmas are often not overturned until proof of the alternative argument can be directly seen (Navy submarines spotting undersea tectonic rifts made tectonic drift become accepted while being able to see bacteria under a microscope did the same for Semmelweis's theory about needing to wash hands to prevent postpartum sepsis).
At the same time, because of the way our scientific system presently works, many have a great deal of difficulty believing anything unless a model exists to explain how something causes something else to happen. Although that initially appeared to be a significant stumbling block for linking the vaccines to these deadly clots, as this article shows, there are clear mechanisms to support it (note: in the previous article I went into additional compelling mechanisms to explain the severe blood clots such as the spike protein vaccine frequently causing antiphospholipid syndrome).
Although there was much I appreciated about Died Suddenly (e.g. it touched upon the history of elitist population control which I presented detailed evidence of here alongside a summary of the known previous attempts to develop and deploy sterilizing vaccines on the public), I feel the lack of editorial control will be extremely problematic later on. Since easily falsifiable information exists in the video that will be focused on in any attempt to debunk it, that will significantly weaken its message and allow the vaccine blood clots to be associated with other unprovable conspiracy theories.
This is a shame because the blood clot aspect of the film is so strong and can easily stand on its own. Additionally, I feel it is very likely that when Died Suddenly is searched in the future, instead of the large numbers of news reports emerging that show where this happened, we will instead be greeted with an endless number of articles debunking those parts of the movie.
The producers of Died Suddenly have my genuine sympathy for these oversights, as I recognize from writing here on complex subjects how easy it is despite my best efforts to make factual errors and as much as I hate to say this "spread misinformation" (this is why I and colleagues periodically volunteer to vet medical information being compiled to challenge this vaccination program).
At the same time however, I also believe once these mistakes are recognized, they need to be addressed. Since I can edit my own written posts after publication, I recognize it is much easier for someone like me to do that than a video publisher, but I nonetheless believe it must also be seriously considered for a documentary that had a limited release to a video-sharing platform.
See Also:
New study claims to show Vitamin D doesn't help against Covid. Here's what they did wrong
Rapid waning and short-lived immunity: It's time to rethink COVID booster shots, Israeli researchers say
"Disturbed and alarmed": 66 doctors, clinicians and scientists call for stop to Covid vaccination of pregnant women over serious safety concerns
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Reader Comments (24)
Buffalo_Ken
Buffalo_Ken · 2 days ago
Here is a good link on what might be causing the clots.
[Link]
From a Midwestern Doctor, well thought out and deserving respect.
Gator
Gator · 2 days ago
Buffalo_Ken Killer article, pardon the pun...
Buffalo_Ken
Buffalo_Ken · 2 days ago
Gator - Gator, I tried to kiss the Midwestern Doctor once and it was on a whim and she took it for what it was and I think she knows her shit.
~
Best to you,
Ken
Buffalo_Ken
Buffalo_Ken · 2 days ago
Gator - I guess the joke is on me and I don't mind......I'm tired of the battle I won't deny...didn't even realize the article was the same till now.....oh well. Oh well. Still, I won't deny I tried to kiss her once, and she didn't say no.....she knew the difference twixt a kiss in person versus one shared online.
Gator
Gator · Buffalo_Ken
· 2 days ago
Gator
Gator · 2 days ago
Buffalo_Ken No worries mate !
Buffalo_Ken
Buffalo_Ken · about 17 hours ago
Gator - you are a good online friend Gator Man, it is so unfair the schedule the Bills have had this season, but I ain't complaining. Adversity builds character is what they say....
However, I can't deny, sometimes I do myself a disservice by not being properly deliberate. There is a song about this my daughter shared with me a long time ago, and later if the time seems proper, I'll post it......it is about slowing down and it is a good song.
Peace,
Ken
Gator
Gator · Buffalo_Ken
· about 11 hours ago
Mayday Mike
Mayday Mike · 2 days ago
Blood clots naturally when there is a cut that needs sealing; ordinarily the cut is a localized event and does not affect the ENTIRE CIRCULATORY SYSTEM; death by a million cuts, across every blood artery, vessel, and capillary. D-dime tests on the vaccinated show clotting on capillaries, the smallest of blood vessels.
Patrick Donnelly
Patrick Donnelly · 2 days ago
Clots are dissolved by enzymes.
SIMPLES!
[Link] a group dedicated to dissolving clots.
Gnostic
Gnostic · a day ago
Patrick Donnelly Do they have a website as I can not view the page. It wants me to log in and I do not have an account.
oldschoolrider
oldschoolrider · a day ago
cayman chemicals
usa made an proud, fkn typical nazi medicine
SN-102 ,,, the clot causing trigger..
nazi maggots fauci, gates soros, shwabby, are on there way to hell, there is no heaven for them for that suffering they created..
so sucks to be them!!
McFluffin
McFluffin · a day ago
So, if they believe they know the cause of the clots, they can work on a cure? I would like to think that this article is one of hope for all those who have had the shots and been injured. Unlike Stew Peters fear mongering, let's look for solutions. This is progress, right?
Baybars
Baybars · a day ago
McFluffin If the documentary is 'fear mongering', then what do you call all the media and government propaganda these past two years in order to get you vaxxinated? Public health alerts?
Baybars
Baybars · a day ago
It is good to critique the documentary because the covidians will do all they can to discredit the film and its makers. That being said, the documentary has no doubt opened many eyes that were previously closed to this side of the covid story and I doubt anyone would mind if the Midwestern Doctor's suggested edits were incorporated.
While that is going on, more films like this should be made.
parzival
parzival · about 24 hours ago
We have been exposed to novel genetically engineered pathogens, designed through gain of function experiments to make people seriously ill. In response, we are bypassing the natural safeguards of digestion by injecting material directly into the body. This material contains microscopic lipid nanoparticles. Particles that are designed to breach the protective cell wall. It also contains instructions designed to alter the way DNA works and/or expresses itself. Once inside the cell, these are capable of transcribing themselves into our nuclear DNA, corrupting its structure.
Once DNA is corrupted, it loses its incredible ability to overcome the second law of thermodynamics. We become subject to the laws of decay, rapid decay. If you want to know why so many people are becoming ill and dying this is it in a nutshell...
parzival
parzival · about 24 hours ago
CDC EMPLOYEES STRUGGLE TO GET RESEARCH PUBLISHED BECAUSE ITS FINDINGS COUNTER PUBLIC HEALTH DOGMA [Link]
Baybars
Baybars · about 23 hours ago
One opinion on what these clots are, and how they got there has been expressed here [Link] A very compelling explanation.
No matter what you think is causing these odd clots, this is an absolute horror that has been let loose on humanity and it appears to be only gaining momentum.
parzival
parzival · about 23 hours ago
Baybars A horror story that looks like calamari...
parzival
parzival · about 23 hours ago
'Bad Hombre Calamari Surrounded by the walking dead with ticking clocks' by GOOD CITIZEN NOV 29
*
Those poor souls lay on their backs on the embalmer’s cold metal tables getting calamari tweezed out of their veins and arteries like a post-mortem seafood factory.
Having their blood drained slowly with black coffee grinds mixed in because that’s the only speed impure blood drains from the victims of Big Pharma assassinations.
Brought to the planet by, Pfizer.
There are some bad hombres in this world, but these hombres aren’t the ones being shuttled across the border in the millions by Narco gangs working with the Biden administration and the Clinton-Soros controlled child protective services paedo trafficker Wayfair Yandex industrial complex.
As bad as all that is, and as brazen as they are advertising their paedo agenda everywhere they can get away with it, including high fashion advertising campaigns, they don’t fill blood vessels with calamari.
Still, we can’t look away from either atrocity and still carry a clear conscience. And yet the media and all the digital nodes of gormless hand-picked nonces with the largest platforms are completely muted on all of it..." [Link]
Baybars
Baybars · about 23 hours ago
parzival That was an entertaining article. Thanks for the link.
At one point the author suggests that, " The U.S. has moved light years beyond Banana Republic status. A whole new category of a corrupt dictatorial surveillance police state with child trafficking, open borders, paedophilic reverence, and corporate socialism, with absolutely no shame about any of it, will need to be invented to accurately label what the nation has become. "
Donald Trump coined a phrase that accurately describes the U.S. today; a shithole country.
With respect to the vaccination uptake quoted in the article, I think it's low. According to other sources, " Over a year into the biggest vaccination campaign in history, more than 12.7 billion doses have been administered across 184 countries. The latest rate was roughly 7.07 million doses a day. ” [Link]
parzival
parzival · about 23 hours ago
Baybars The Bloomberg article seems more realistic. The death count will be staggering in the years to come...
parzival
parzival · about 23 hours ago
CDC quietly confirms at least 118k Children & Young Adults have ‘Died Suddenly’ in the USA since the roll-out of the COVID Vaccines BY THE EXPOSÉ ON NOVEMBER 30, 2022 [Link]
*
"Official figures quietly published by the U.S. Centers for Disease Control (CDC) confirm nearly half a million children and young adults have died ever since the Food & Drug Administration first granted emergency use authorisation to a Covid-19 vaccine in the USA.
This has sadly resulted in nearly 118,000 excess deaths compared to the 2015-2019 average.
The figures also reveal that there have been 7,680 more excess deaths among children and young adults in 2022 so far compared to the same time frame in 2020 at the height of the alleged Covid-19 pandemic.
But the year 2021 was by and large the worst year for deaths among 0 to 44-year-olds, with 291,461 excess deaths in total, nearly 60,000 more than occurred in 2020. And according to the official CDC figures, this was mainly due to a mysterious sudden rise in deaths among children and young adults from around week 31 onwards.
Unfortunately, according to data published by the UK Government, that “mysterious” sudden rise which has contributed to half a million American children and young adults dying since late 2020, is most likely due to the Covid-19 injections..."
parzival
parzival · about 22 hours ago
Meanwhile in Japan, a pissed off Dr Masanori Fukushima, Professor Emeritus at Kyoto University, warns about vax harms to the Ministry of Health: "You are ignoring science! It's a disaster. You spend billions on the vaccine & force people to inject it...due to the vax, natural immunity has been suppressed" [Link]
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Latest News
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Daughter: "Daddy what are sanctions?" Father: "Nothing to worry about kiddo."
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Few people have the imagination for reality.
Putin can never negotiate with Biden. The Great American Empire is an Oil and Gas Junky. The US has a Terminal Cancer; It has a Vampire Blood...
shootinputin
Not finding it here, I went to the originating site [Link] for the vid'
Good Optics
Looks like SanFran will get it's own Robocop statue soon enough. Or maybe it'll just end up like Detroit?
AutomatedMan
Possibly a desperate attempt to bring back American leftists who left in disgust when they hung Assange out to dry?
JohnnyQuest
Very informative video about the England's doings behind the scene pre WW2.
Demore
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4 jan 2022
Desde a sua identificação na África do Sul, graças a um excelente serviço de vigilância genômica, a variante #ômicron do vírus #SARS-CoV-2 tem gerado incertezas que a ciência começa, lentamente, a resolver. As perguntas mais urgentes tratam da transmissibilidade e capacidade de causar doença grave. Dados epidemiológicos iniciais sugeriam que os infectados por ômicron apresentavam menos quadros graves e precisavam menos de cuidados hospitalares. Mas estes dados incluíam populações jovens, vacinadas ou parcialmente vacinadas, ou que apresentavam imunidade previa para #COVID-19. Ou seja, a doença “leve” podia ser uma característica dos doentes, não do vírus.
A outra questão dizia respeito à capacidade, também aparente, da variante ômicron se transmitir de forma mais efetiva do que a delta, e assim, assumir um papel dominante. Seria essa capacidade fruto de uma característica biológica da ômicron, algo na sua fisiologia que confere vantagem ao se replicar ou ao infectar uma célula? Ou seria algo gerado pela sua capacidade – essa comprovada de forma inequívoca – de escapar parcialmente das vacinas disponíveis até agora?
Se a variante escapa de vacinas, ela circula mais, pois circula também entre vacinados. Então fica a dúvida: ela seria mais transmissível porque escapa das vacinas e imunidade prévia, e com isso ganha a competição com a delta, que não tem essa capacidade? Ou seria mais transmissível porque tem vantagens fisiológicas? Ou ambos? Para responder a essas perguntas, precisamos de experimentos bem planejados e executados em células e, principalmente, em animais, que se somem aos dados epidemiológicos.
Infelizmente, com tem sido a marca desta pandemia, o afã de publicar muito e publicar rápido que tomou conta da comunidade científica tem gerado mais ruído do que informação relevante. A cultura dos preprints, por um lado necessários para compartilhar informação cientifica entre os pares, traz também ondas de interesse midiático sobre resultados fracos e carentes de confirmação, ondas que mais confundem do que iluminam. A atuação de influencers que agarram o megafone para amplificar rapidamente o canto do galo, que vem não se sabe de onde, também não ajuda.
O que sabemos, afinal, sobre a variante ômicron, com os estudos que foram feitos até agora? Para entender as questões da transmissibilidade, escape de vacinas, e doença leve ou grave, precisamos rever alguns conceitos.
Mutações
A variante ômicron aparece com 50 mutações, sendo 30 somente na proteína S, da espicula, que é a chave que “abre as portas” da célula humana para o vírus. O número de mutações em si não é preocupante, mas sim os tipos. Algumas dessas mutações eram conhecidas de outras variantes, e conferiam realmente características de escape de vacinas e maior transmissibilidade.
Além de ser responsável pela entrada do vírus na célula, a proteína S serve de alvo para os anticorpos do tipo neutralizante, que impedem a infecção. Mutações neste local são preocupantes quando alteram a proteína a ponto de os anticorpos gerados por vacinas ou por infecção prévia não conseguirem mais reconhecê-la. No caso da ômicron, a capacidade de enganar esses anticorpos certamente existe.
Também na proteína S fica o sítio de ligação ao receptor (RBD em inglês, receptor binding domain). Neste sítio, foram encontradas mudanças já vistas em outras variantes, e que sabemos que aumentam a afinidade pelo receptor celular: a “chave” encaixa melhor na “fechadura”. Essas mutações acenderam mais um sinal de alerta.
virus
A proteína S, no entanto, não é uma chave que já chega pronta para funcionar. Para permitir que o vírus invada a célula, ela precisa ser ativada, num processo de duas etapas. Na primeira, a “S” é cortada, por uma molécula chamada furina, em duas partes, chamadas, de modo bem criativo, de S1 e S2, que vão, cada uma, atacar uma porta de entrada diferente. A S1 se liga a um receptor celular chamado ACE2, mas a S2 precisa ser cortada outra vez. Esse segundo corte é feito por enzimas presentes na própria membrana da célula atacada – quem cumpre esse papel de “traidora” é a enzima TMPRSS2 ou a catepsina.
Quando é a TMPRSS2 que facilita a vida do vírus, a entrada se dá por fusão de membrana. Já quando quem atua é a catepsina, o vírus invade a célula por meio de um endossomo – uma espécie de “táxi” que o carrega para o lado de dentro da célula.
Algumas mutações aumentam a afinidade da proteína S pela furina, e ajudam a melhorar a infectividade do vírus. Isso foi observado na variante delta, e a ômicron apresentou mudanças similares.
Além disso, a ômicron apresenta uma série de mutações que alteram uma das partes da proteína S que mais chama a atenção de anticorpos (“supersítio antigênico NTD”, caso alguém esteja curioso). É como se a polícia estivesse procurando um suspeito loiro e o bandido resolvesse pôr uma peruca ruiva. Isso ajuda o vírus a escapar de anticorpos gerados por vacinas ou infecção prévia.
Assim, vemos que havia motivos para preocupação. Havia precedentes que permitiam prever, com alguma segurança, que a ômicron escaparia de vacinas e seria mais transmissível. Mas previsões precisam ser testadas. O que os estudos epidemiológicos e de laboratório mostraram?
Transmissibilidade
Dados epidemiológicos mostraram que a ômicron realmente se espalha mais rapidamente, e acaba tirando a delta de circulação. Na cidade de Nova York, a variante já é responsável por mais de 90% dos casos reportados, e o mundo registra 1,5 milhão de casos novos diariamente. Só nos EUA, o número de novos casos diários chegou em 400 mil, com aumento de 31% em hospitalizações e 37% em mortes, comparado com a última semana de dezembro. O maior impacto é em não vacinados.
Sabendo que a ômicron escapa de vacinas, esta velocidade toda seria só por causa do olé que ela dá nos anticorpos pré-existentes, ou existe alguma vantagem adaptativa fisiológica no vírus, uma capacidade maior de se replicar ou de se transmitir?
Para responder a esta pergunta, pesquisadores de Hong Kong fizeram testes em culturas de células, e constataram, em ensaios preliminares, ainda não publicados, que a ômicron teria capacidade de se replicar 70 vezes mais depressa do que a delta em células dos brônquios. Em células pulmonares, ao contrário, a ômicron teria mais dificuldade em se reproduzir.
Se isso se confirmar, poderia ser uma explicação para o aparente caráter mais leve da doença causada pela variante: se o vírus tem vantagem replicativa nas células do trato respiratório superior, e, portanto, também uma maior transmissibilidade, mas menor capacidade de infectar o pulmão, ele se espalha mais fácil, mas é menos capaz de causar pneumonia e outras complicações.
A perda da TMPRSS2
Para testar essa hipótese, de que realmente a ômicron teria se especializado em células do trato respiratório superior, e perdido competência no pulmão, alguns laboratórios realizaram testes em cultura de células e em animais.
O primeiro preprint a aparecer sobre o assunto – um artigo não revisado pelos pares e ainda não publicado em periódico científico –, foi o do grupo do professor Ravindra Gupta, da Universidade de Cambridge. Experimentos feitos com cultura de células sugerem que a ômicron tenha perdido sua capacidade de entrar na célula via fusão de membrana, caminho que depende da enzima TMPRSS2. Os pesquisadores testaram a capacidade da ômicron de invadir células com ou sem TMPRSS2, comparando com a delta, e perceberam que a delta depende muito mais dessa enzima do que a ômicron, que parece não se importar com ela, sugerindo que deve estar utilizando um outro caminho.
virus
A via mais provável seria a do endossomo, que usa a catepsina. A hipótese é boa, mas devemos examiná-la com cautela. Os autores afirmam, por exemplo, que as células do trato respiratório superior não têm TMPRSS2, o que corrobora a hipótese de que a ômicron esteja em vantagem ali e em desvantagem no pulmão, rico em TMPRSS2. Embora as células do pulmão realmente expressem a enzima em grande quantidade, não é verdade que ela esteja ausente das vias superiores. Há relatos da presença da TMPRSS2 em células olfativas e células dos brônquios.
Outro cuidado a tomar é não extrapolar conclusões para além do que o estudo permite afirmar. Uma coisa é mostrar que a variante está em desvantagem no pulmão, porque perdeu uma importante via de entrada. Outra é inferir que esta perda também causa vantagem no trato superior, ou que garante que a única via utilizada é a de endossomo. Pode ser que haja outra enzima fazendo as vezes da TMPRSS2, ou ainda, outro caminho de infecção, ainda não detectado, usado pela ômicron e que traz vantagem nas vias aéreas superiores.
Para testar essa hipótese de maneira mais conclusiva, o ideal seria trabalhar com um único tipo celular, e fazer deleções dos genes que codificam para TMPRSS2 e para catepsinas, testando cada uma das possíveis entradas. Neste artigo publicado e revisado pelos pares, pesquisadores de Hong Kong fizeram um estudo mais detalhado que fornece pistas importantes.
Utilizando uma linhagem de células que expressava TMPRSS2 em excesso, os pesquisadores compararam a capacidade das variantes delta e ômicron de infectar e se replicar. A delta levou vantagem nas células que expressavam TMPRSS2. Quando os autores inibiram a atividade da enzima com um agente químico, a delta foi afetada, mas a ômicron não, sugerindo que realmente a nova variante utiliza um caminho alternativo, possivelmente a via de endossomo mediada por catepsinas. Quando os pesquisadores usaram um inibidor da via de endosssomo, tanto a delta como a ômicron foram prejudicadas. Os autores também observaram menor fusão de membrana na variante ômicron, o que confirma a provável perda da entrada mediada pela TMPRSS2.
Eles também fizeram ensaios de competição entre a delta e a ômicron nos dois tipos celulares: com e sem TMPRSS2. A delta ganhou na presença da enzima e a ômicron ganhou nas células sem TMPRSS2, mostrando que é possível que a ômicron esteja usando de forma mais eficiente a via de endossomo, mas ainda não é possível afirmar que esse é o único caminho.
Os dados explicam a desvantagem da ômicron no pulmão, o que pode por sua vez confirmar que esta variante causa doença mais leve, mas falta explicar o maior sucesso nas vias aéreas superiores. Outras hipóteses podem ser úteis aí, como este trabalho publicado na Nature, sugerindo que uma mutação que inibe a resposta imune inata poderia ser responsável.
Experimentos feitos com hamsters sírios e camundongos confirmaram que a ômicron não coloniza muito bem o pulmão dos animais, pelo menos no período observado, de quatro dias para os hamsters, e seis dias para os camundongos. Em ambos os estudos, encontrou-se menos inflamação e menor carga viral no pulmão dos animais infectados com ômicron. Estes estudos estão alinhados com a hipótese da perda do acesso via TMPRSS2, mas novamente, embora ofereçam uma explicação para o fato de que a ômicron parece causar doença mais leve, não oferecem explicação para sua maior transmissibilidade.
Evolução
Em geral, a perda um mecanismo patogênico ocorre de acordo com pressão seletiva e economia de energia. Se a via de fusão de membrana é desnecessária, existe uma grande probabilidade de que venha a desaparecer com a passagem do tempo. A peculiaridade da ômicron não é tão peculiar assim. Estudo publicado em junho de 2021 obteve mutantes de SARS-CoV-2 muito semelhantes à ômicron neste quesito, simplesmente selecionando variantes cultivadas em células sem TMPRSS2, as famosas células VERO, de rins de macaco. São células genéricas em que a entrada do vírus ocorre necessariamente por via de endossomo, e é bloqueada com sucesso – apenas in vitro – pela cloroquina ou outros inibidores de catepsina.
Apenas cinco dias de passagem do vírus em células VERO sem a TMPRSS2 foi suficiente para selecionar mutações que levaram à perda da capacidade de usar essa enzima para entrar na célula.
virus
Uma das conclusões do artigo sobre esses mutantes de laboratório difere do observado no caso da ômicron: os mutantes de laboratório não pareciam ter vantagem sobre o vírus natural. Ou seja, perder uma via de entrada não é necessariamente uma boa notícia para o vírus – o que faz sentido (afinal, ele se tornou menos versátil). A vantagem de replicação e competição observada para a variante ômicron pode, portanto, ter outra causa. Na verdade, estudos anteriores mostram que a via de fusão de membrana confere uma capacidade infectiva de 100 a 1.000 vezes maior do que a via de endossomo.
Célula a célula
Estudo publicado no periódico PNAS mostra que o vírus SARS-CoV-2 pode se transmitir de célula para célula, sem precisar primeiro sair de uma célula infectada para depois penetrar em outra. Ao se propagar diretamente entre células, o vírus não só aumenta sua infectividade, como também escapa da resposta de anticorpos, que dependem do reconhecimento dos invasores no ambiente extracelular.
Pode-se especular que talvez esse seja um dos mecanismos da variante ômicron que permite uma maior transmissibilidade, mesmo na ausência da TMPRSS2. Seria também vantagem para escapar de anticorpos. Não existe ainda nenhum dado experimental sobre a capacidade da ômicron de se propagar direstamente entre células. No momento, trata-se apenas de um exercício para ver como é possível imaginar outros mecanismos celulares que poderiam explicar a maior transmissão de ômicron nas vias aéreas superiores, na ausência de uma importante via de entrada.
E a cloroquina?
Para quem acompanhou a triste saga da cloroquina, a perda da via de fusão de membrana acende um alerta de possível retrocesso à cura milagrosa. Uma das razões que fazia da cloroquina uma péssima aposta para tratar a COVID-19 era justamente o fato de que ela não poderia funcionar nas células do trato respiratório, ricas em TMPRSS2, pois a via de entrada preferencial era independente do endossomo – o mecanismo que o antimalárico inibe, ao menos in vitro. Mas a dependência do SARS-CoV-2 original (e das variantes conhecidas, até a delta) em relação à enzima era apenas uma das razões, entre várias, para descartar a cloroquina.
As demais baseavam-se nos fatos de que a cloroquina já foi testada para um enorme número de outras viroses e nunca funcionou: todas as tentativas de reproduzir seu sucesso contra vírus (observado em células de laboratório) para organismos vivos, completos e complexos, fracassaram. Além disso, a cloroquina foi testada – sem o mínimo grau de sucesso – em modelo animal, em todas as fases da COVID-19, de forma profilática, profilática pós-exposição, em casos leves, moderados e graves, com ou sem azitromicina. E nunca funcionou.
Assim como também não funcionou em testes clínicos controlados. Isso tudo já foi exaustivamente estudado e divulgado, inclusive e especialmente por esta revista, aqui, aqui e aqui.
Por que então funcionaria para a ômicron, sem nunca antes ter funcionado, ainda que parcialmente, para as variantes anteriores? As demais variantes nunca perderam a capacidade de invadir via endossomo. Em células VERO, que não têm TMPRSS2, a cloroquina inibe igualmente delta e ômicron.
De acordo com as alegações do preprint do grupo de Cambridge, a expressão de TMPRSS2 é maior no pulmão e inexiste nas vias superiores. Sabemos que isso não é verdade – a literatura indica a presença da enzima no trato superior –, mas mesmo que a expressão seja menor nas vias superiores, isso significaria que a delta ou qualquer das variantes anteriores deveria depender da via de endossomo no trato respiratório superior. E seriam neutralizadas ali, portanto, por inibidores dessa via, o que nunca aconteceu.
O fato de a cloroquina funcionar in vitro mas não em organismos pode ter muito mais razões do que simplesmente as diferentes vias de entrada do vírus. Pode estar relacionado a biodisponibilidade, farmacocinética e dosagem.
O rebanho
Outra falsa controvérsia ressuscitada das trevas é a da imunidade de rebanho natural. Já que a ômicron é mais branda, diz o mau argumento, então agora sim vale a pena todo mundo se infectar, ninguém vai ter doença grave, é uma “vacina natural”.
É um argumento ruim, porque falacioso. Realmente, a ômicron parece causar doença menos grave do que a delta, e os dados de modelo animal reforçam essa impressão. Ao mesmo tempo, vemos um número crescente de hospitalizações entre não vacinados. Ainda que o número relativo de hospitalizações causadas pela ômicron seja menor do que a delta, em números absolutos, por se tratar de uma variante mais transmissível, ainda vai ter muita gente no hospital. Imagine que a ômicron tem uma taxa de hospitalização que é 50% da taxa da delta. Mas infecta o triplo de pessoas. Mesmo sem fazer conta nenhuma, dá para perceber que metade de um monte de gente ainda é um monte de gente, certo?
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Não sabemos o quanto a ômicron é menos grave em humanos. E como sabemos que ela é mais eficiente em se transmitir, e se transmite entre vacinados, a probabilidade de chegar a pessoas vulneráveis é muito grande. O potencial de causar estrago da ômicron ainda é desconhecido e, diante destas incertezas, é preciso cautela. Os efeitos sociais também precisam ser levados em conta, pois com esta alta taxa de contaminação, a ômicron está acometendo equipes inteiras de trabalhadores de saúde.
Assim, pessoas vulneráveis ainda podem desenvolver doença grave e morrer por falta de equipe médica e de enfermagem. Isso sem nem entrar no mérito de sequelas e Covid longa, que podem ocorrer mesmo em casos leves e moderados. Imunidade de rebanho “natural” continua sendo uma péssima ideia. Principalmente porque temos vacinas. Não há nada que justifique adoecer de uma doença evitável ou atenuável por vacinação.
Para resumir: a ômicron é mais transmissível? É menos grave? Escapa de vacinas? As respostas são sim para a primeira questão, mas ainda não sabemos exatamente por quê; um sim cauteloso para a segunda, porque parece causar doença menos grave em animais e ter dificuldade para se replicar no pulmão, mas não sabemos o quanto é menos grave em humanos, e o que isso significa em termos epidemiológicos; e definitivamente sim para a última: a ômicron escapa de vacinas e se transmite entre vacinados, porém as vacinas continuam servindo para proteger contra doença grave e morte.
O que isso muda na prática? Nada. A não ser por trazer um alívio de que a cepa dominante agora pelo menos parece menos letal, a ômicron não muda a necessidade de uma terceira dose de vacina – pelo contrário, aumenta, já que estudos mostram que três doses aumentam a proteção contra esta variante – e não reduz a necessidade do uso de máscaras e cuidados com o distanciamento social. O que a ômicron muda é nossa consciência social de que ou vacinamos o mundo inteiro o mais rápido possível, ou podemos não ter tanta sorte na próxima variante.
Natalia Pasternak é microbiologista, pesquisadora associada do Instituto de Ciências Biomédicas da USP, professora da Fundação Getúlio Vargas (FGV), presidente do Instituto Questão de Ciência, membro do Committee for Skeptical Inquiry (CSI), colunista do jornal O Globo e coautora de "Ciência no Cotidiano" (Editora Contexto), obra vencedora do Prêmio Jabuti em 2021, e "Contra a Realidade"(Papirus 7 Mares). Atualmente, é professor adjunta em Columbia University.
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