0 Persons are tagged with #genetics

#genetics

jjc@societas.online
John Jaarsveld

Research explores how a father's diet could shape the health of his offspring
A step towards understanding how the effect of diet could transmit from one generation to the next.
A mice study suggests a father's diet may shape the anxiety of his sons and the metabolic health of his daughters before they are even conceived.

https://www.sydney.edu.au/news-opinion/news/2024/04/17/research-explores-how-a-father-s-diet-could-shape-the-health-of-.html
#health #diet #genetics #fathersmatter

Research explores how a father’s diet could shape the health of his offspring

New research, published in Nature Communications, finds that the macronutrient balance in the diet of male mice affects the level of anxiety-like behaviour of sons and the metabolic health of daughters.

waynerad@diasp.org
Wayne Radinsky

"Hackers stole ancestry data of 6.9 million users from 23andMe."

"23andMe describes the DNA Relatives feature as 'one of the most interactive features' offered on the site, 'allowing you to find and connect with genetic relatives and learn more about your family.' By opting in, users hope to find lost family members by willingly giving others access to information like their birth year, current location, and ancestors' names and birth locations."

"The largest group, spanning about 5.5 million users, was hacked after opting in to automatically sharing information with DNA Relatives, including their 'name, birth year, relationship labels, the percentage of DNA shared with relatives, ancestry reports, and self-reported location." "The smaller group, about 1.4 million users, shared 'Family Tree profile information' that was hacked, including display names, relationship labels, birth year, and self-reported location."

Always thought about who DNA sequencing companies might voluntarily reveal the data to -- hadn't thought about what if they were simply hacked. And wonder who wanted this data and why?

Hackers stole ancestry data of 6.9 million users, 23andMe finally confirmed

#solidstatelife #cybersecurity #genetics

Hackers stole ancestry data of 6.9 million users, 23andMe finally confirmed

Majority of impacted users are now being notified.

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tpq1980@iviv.hu
T Q

GDP Per Capita & National Mean IQ for 240 Countries & Dependencies, using Pearson Sample Correlation Coefficient, 2023.

This demonstrates that as mean IQ goes down, GDP Per Capita also goes down, or conversely, as mean IQ goes UP, GDP Per Capita also goes up, with a 0.63 (strong) correlation.

This is in relationship to the graph provided at the following link: https://iviv.hu/posts/1527586

#gdp #gdppercapita #iq #nationalmeaniq #intelligence #intelligencequotient #trend #correlation #data #research #analysis #uk #usa #economics #statistics #civilization #wealth #society #anthropology #genetics #genotypes #neurology #systems #un #eu #europe #asia #africa #middleeast #gnp #wealthcreation #societalsystems #growth #development #competency #mentalability

kennychaffin@diasp.org
Kenny Chaffin

By analyzing the genomes of more than 335,000 people and using questionnaires to assess their meat intake, scientists have identified one point in the human genome — rs72884519 on chromosome 18 — that is significantly associated with following a vegetarian diet. In a separate analysis, the researchers identified three gene variants — NPC1, RMC1, and RIOK3 — clustered in that same region that are linked to vegetarianism, as well as another 31 genes elsewhere in the genetic code that may have a "possible role" in this dietary choice.

https://www.livescience.com/health/genetics/going-vegetarian-the-dietary-choice-may-be-influenced-by-your-genes

#science #biology #genetics

Going vegetarian? The dietary choice may be influenced by your genes.

A new analysis of more than 330,000 genomes has revealed specific gene variants that may be associated with vegetarianism.

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tpq1980@iviv.hu
T Q

Correlative Trend Between GDP Per Capita & National Mean IQ for 240 Countries and Dependencies, 2023.

Logic suggests that the higher the mean IQ a people-group exhibits, the more capable they will be to discover, invent, implement, maintain, grow & iterate the complex, interacting societal systems that support economic development & wealth creation.

#gdp #gdppercapita #iq #nationalmeaniq #intelligence #intelligencequotient #trend #correlation #data #research #analysis #uk #usa #economics #statistics #civilization #wealth #society #anthropology #genetics #genotypes #neurology #systems #un #eu #europe #asia #africa #middleeast #gnp #wealthcreation #societalsystems #growth #development #competency #mentalability

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devevo@diasp.org
7B'JaJaDa

#biology #evolution #genetics #mitochondria
Amazing Discovery Reveals Why You Didn't Get Your Dad's Mitochondria
Virtually every animal on Earth can thank their mother for the energy that fuels each of their cells.
The power is generated in a part of the cell known as the mitochondria, and this organelle is made entirely from a genetic recipe laid out in your mother's DNA...
...The findings do not explain why, in rare circumstances, scientists have found mtDNA transmission in some humans that looks as though it came from both the father and the mother. But it might help experts better understand some fertility disorders, which can be passed down through eggs or sperm...
https://www.sciencealert.com/amazing-discovery-reveals-why-you-didnt-get-your-dads-mitochondria

Amazing Discovery Reveals Why You Didn't Get Your Dad's Mitochondria

Virtually every animal on Earth can thank their mother for the energy that fuels each of their cells.

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waynerad@diasp.org
Wayne Radinsky

A CRISPR-free DNA editing system has been invented. It is claimed it can do effective base editing in the nucleus, mitochondria, and chloroplast genomes of plant and human cells.

The alternative system is called CyDENT and it's based on a preceding technology TALE. "TALE" stands for "transcription-activator-like effector". Before explaining what CyDENT is about, it might first be worthwhile to explain a bit about TALE. TALE proteins, which were discovered in bacteria (Xanthomonas bacteria, if you care to know), have the special property that they can be reconfigured to match any DNA sequence. To make these proteins work as gene editors, they are fused to something called a deaminase. A deaminase, in turn, is a fancy word that means a protein that can convert one DNA base to another. For example there are deaminases that convert C to T.

The shortcoming of this system is that the deaminases are themselves double-stranded pairs of DNA. The bases that they edit likewise have to be double-stranded. The new CyDENT base editing system fuses TALES with a single-strand-specific cytidine deaminase that has been found called FokI nickase.

There are some additional components: an exonuclease and a uracil glycosylase inhibitor. Exonucleases pop nucleotides off the end of a DNA strand one at a time. They are called "exo" because there's such a thing as endonucleases, which operate in the middle of a DNA strand. There are different exonucleases depending on which end of the DNA strand you want to pop, and there are exonucleases for RNA, too.

I have no idea what the uracil glycosylase inhibitor is for. A uracil glycosylase inhibitor is a protein that inhibits uracil DNA glycosylase, which is an enzyme that removes uracil from DNA. It's considered a "repair" enzyme. RNA uses uracil while DNA uses thymine. So if there's any uracil in DNA, it shouldn't be there.

Ok, at this point we turn our attention back to the main actor, the FokI nickase. It's called a "nickase" because it "nicks" DNA strands. Great name, eh? In case you're wondering, no, the "Fokl" part of the name doesn't come from the great Dr. Fokl, it comes from the name of the bacteria where it was discovered, Flavobacterium okeanokoites.

So the idea is that the TALE proteins find the target strand of DNA, the Fokl nickase "nicks" the DNA strand, exposing the desired region, the exonuclease pops nucleotides off one strand, leaving a short single stranded DNA segment. The DNA deaminase steps in here and modifies the DNA in the single-stranded segment.

If you're wondering what the point of all this is, it allows editing of single-stranded DNA in the absense of a bunch of stuff CRISPR requires, in particular the Cas9-guided R-loop structure and double-stranded DNA deaminases mentioned in the article. The R-loop structure is a complex 3-dimensional structure that forms when the Cas9 protein that the CRISPR system relies on finds its DNA target. Believe it on not, this structure involves the RNA strand that is the "guide" for the CRISPR editing process to form a "hybrid" double helix with one of the DNA strands -- the the "R-loop" actually consists of an RNA-DNA helix and a single-stranded DNA loop that is intertwined with the RNA-DNA helix.

Apparently it is really crucial for the system to be RNA-free, as that is the key to enabling it to work in the nucleus and in "organellar genomes" such as mitochondria and plant chloroplasts.

This might be a good time to tell you what CyDENT stands for, now that you'll understand all the terms in it. It stands for "cytosine deamination by nicking and editing technology".

Scientists Develop novel base editors - Institude of Genetics and Developmental Biology, Chinese Academy of Sciences

#discoveries #biology #genetics #geneediting #crispr

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devevo@diasp.org
7B'JaJaDa

#biology #genetics #evolution
Tweaking Just a Few Genes Transforms Scales Into Feathers
The feathers, fur, and scales that adorn different members of the animal kingdom may look quite different, but they're all made of the same basic stuff. And, as it turns out, it only takes a relatively simple genetic tweak to produce one instead of the other...
https://www.sciencealert.com/tweaking-just-a-few-genes-transforms-scales-into-feathers

Tweaking Just a Few Genes Transforms Scales Into Feathers

The feathers, fur, and scales that adorn different members of the animal kingdom may look quite different, but they're all made of the same basic stuff.

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tpq1980@iviv.hu
T Q

Composite map of J1 & J2 Y-Haplogroup distribution in Europe, parts of North Africa & parts of the near-East. Interesting to see the clustering spikes in Italy, France, Southern UK, Southern Sweden, Turkey, Russia, Albania, Moldova & Corsica. Why cluster here?

#haplogroups #haplogroupclustering #ethnography #j1 #j2 #ethnicity #eu #ethnolinguistics #genetics #jews #jewish #afroasiatic #migration #usa #diaspora #jewishdiaspora #europe #uk #africa #neareast #italy #france #sweden #russia #albania #moldova #corsica #immigration #infiltration #elevation #nepotism #usurpation #corruption #destruction #semitism #abrahamism #ideologicalhegemony #abrahamicideologicalcolonialism #judeoangloamericanempire #usa #map #cartography #elites #elitism #globalism #globalists #control

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